Du very bestämmer själv vilka kakor som får lagras i din webbläsare genom att kryssa website i de kakor som du godkänner nedan. Du kan läsa mer om användningen av kakor på informationssidan.
Pethidine's obvious in vitro efficacy as an antispasmodic agent is because of its nearby anesthetic results. It doesn't have antispasmodic effects in vivo.[33] Pethidine also has stimulant effects mediated by its inhibition with the dopamine transporter (DAT) and norepinephrine transporter (Internet).
If methylene blue need to be administered, discontinue serotonergic drug instantly and observe for CNS toxicity. Serotonergic therapy can be resumed 24 several hours just after previous methylene blue dose or following two weeks of checking, whichever comes very first.
Fråga om läkemedlet Sök apotek med läkemedlet i lager Sök lagerstatus Petidin APL
If needed, meperidine could possibly be specified intravenously, but injection should be provided quite gradually, if possible as diluted Option; fast intravenous injection of narcotic analgesics, like meperidine, increases incidence of adverse reactions; extreme respiratory despair, apnea, hypotension, peripheral circulatory collapse, and cardiac arrest have occurred; meperidine shouldn't be administered intravenously unless a narcotic antagonist and amenities for assisted or controlled respiration are right away out there; when meperidine is specified parenterally, In particular intravenously, the affected person need to be lying down
lasmiditan, meperidine. Either improves outcomes of the other by sedation. Use Caution/keep track of. Coadministration of lasmiditan and other CNS depressant medicine, together with Liquor have not been evaluated in scientific studies. Lasmiditan may induce sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
procarbazine and meperidine both enhance serotonin concentrations. Contraindicated. mix is contraindicated within just two weeks of MAOI use.
Pethidine should be utilized with caution or in lessened doses in individuals with myasthenia gravis. Pethidine need to only be used with caution and in reduced dosage in neonates and premature infants, elderly and debilitated individuals and in patients with head accidents, critical hepatic or renal impairment.
Contraindicated (1)nirmatrelvir/ritonavir will improve the amount or effect of meperidine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Meperidine is taken into account a significant-notify drug within the US as a result of a big chance of risky Negative effects when Employed in error. Newer and safer opioids for soreness management are actually obtainable.
Antipsychotics significant hypotension may well come about when pethidine is administered to people whose skill to maintain blood pressure has actually been compromised by a depleted blood volume or via the administration of prescription drugs which include phenothiazine.
If opioid use is needed for a chronic interval inside a pregnant female, suggest the client of the potential risk of neonatal opioid withdrawal syndrome and be certain that suitable procedure will likely be accessible
Pethidine is promptly hydrolysed during the liver to pethidinic acid and is likewise demethylated to norpethidine, that has 50 percent the analgesic action of pethidine but a longer elimination fifty percent-existence (8–12 hrs);[39] accumulating with frequent administration, or in kidney failure. Norpethidine is toxic and has convulsant and hallucinogenic outcomes.
Trots att det är samma läkemedel kan det i vissa drop fileörekomma skillnader mellan parallellimporterade och direktimporterade läkemedel, t ex avseende färgämnen eller texten på innerförpackningen.